Ovotoxicant VCD disrupts oocyte meiosis in mice by impairing m6A/IGF2BP3-mediated mRNA stability
Yang Li, Yuling Zhou, Jian Liu, Guangning Nie, Fangping Cheng, Hongyan Yang · 2025
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Description
Yang Li and co-authors report mouse research from two thousand twenty-five on an industrial chemical that harms eggs in the ovary. The chemical, called VCD, is known to destroy follicles and shrink the egg reserve. How it breaks the cell division that eggs need, called meiosis, was unclear.
The team found that exposure raises oxidative stress and causes severe errors when chromosomes separate. The chemical disturbs a system that marks RNA with chemical tags, changing which messages stay stable. One RNA-reading protein falls, which destabilizes genes needed to line up chromosomes and build the spindle. The authors say the pathway could be a target to protect fertility from such pollutants.
Catalog record
| CREATOR | Yang Li, Yuling Zhou, Jian Liu, Guangning Nie, Fangping Cheng, Hongyan Yang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |