A comparison of poly(methyl methacrylate) and silorane-based cements as carriers for local doxorubicin delivery
Grahmm A. Funk, Elizabeth M. Menuey, Zachary D. Denton, Dalan M. Pittz, Alejandro Parrales, Tomoo Iwakuma, Kathleen V. Kilway, Terence E. McIff · 2025
Read A comparison of poly(methyl methacrylate) and silorane-based cements as carriers for local doxorubicin delivery by Grahmm A. Funk, Elizabeth M. Menuey, Zachary D. Denton, Dalan M. Pittz, Alejandro Parrales, Tomoo Iwakuma, Kathleen V. Kilway, Terence E. McIff (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12783310.txt.
Description
Grahmm A Funk and co-authors compared two bone cements as local carriers for a cancer drug, in a study published in 2025. After a bone tumor is removed, cement fills the gap and steadies the bone. Loading that cement with the drug doxorubicin could attack leftover cancer cells right where they hide.
The standard cement weakened when the drug was mixed in, and drug released from it killed cancer cells less well in dishes. The likely cause is a clash between the drug and the cement's hardening chemistry. A newer cement based on different chemistry kept its strength with the drug aboard, and its released drug worked at full strength. The authors present the newer material as a strong candidate where bones must bear load and deliver treatment at once.
Catalog record
| CREATOR | Grahmm A. Funk, Elizabeth M. Menuey, Zachary D. Denton, Dalan M. Pittz, Alejandro Parrales, Tomoo Iwakuma, Kathleen V. Kilway, Terence E. McIff |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |