A bioengineered vinpocetine- and menstrual blood stem cell-loaded neural conduit for treating peripheral nerve injury after bone fractures
Guoshan Li, Yuxin Yan, Yong Hou, Guangsheng Zhao, Xiaodong Wang, Min Cui, Huyu Du · 2025
Read A bioengineered vinpocetine- and menstrual blood stem cell-loaded neural conduit for treating peripheral nerve injury after bone fractures by Guoshan Li, Yuxin Yan, Yong Hou, Guangsheng Zhao, Xiaodong Wang, Min Cui, Huyu Du (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12783176.txt.
Description
Guoshan Li and six colleagues engineer a nerve repair tube loaded with a drug and stem cells, in a study published in two thousand twenty-five. Peripheral nerve injuries after fractures often heal incompletely. A guidance conduit that also delivers therapy could close the gap.
The scaffold electrospins polycaprolactone with collagen into a tube. Inside sits a collagen gel carrying vinpocetine nanoparticles and menstrual blood-derived stem cells. Laboratory tests checked structure, mechanics, cell survival, and blood compatibility. Rats with severed sciatic nerves then tested real recovery. Motor and sensory function, muscle preservation, and axon regrowth were measured. The menstrual blood cells are an accessible, ethically simple stem cell source. The design stacks several healing aids into one implant.
Catalog record
| CREATOR | Guoshan Li, Yuxin Yan, Yong Hou, Guangsheng Zhao, Xiaodong Wang, Min Cui, Huyu Du |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |