New insights into the mechanism of microvascular rarefaction via endothelial-mesenchymal transition in steroid-induced osteonecrosis of femoral head
Xiaoqiang Yang, Peng Yang, Jiaru Liao, Fan Yang, Mincong He, Ziqi Li, Qiushi Wei, Wei He · 2025
Read New insights into the mechanism of microvascular rarefaction via endothelial-mesenchymal transition in steroid-induced osteonecrosis of femoral head by Xiaoqiang Yang, Peng Yang, Jiaru Liao, Fan Yang, Mincong He, Ziqi Li, Qiushi Wei, Wei He (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12783121.txt.
Description
Xiaoqiang Yang and co-authors study bone death in the hip joint in this 2025 study. Steroid drugs can kill bone at the top of the thigh bone, in part because small blood vessels there thin out and vanish. The team asked whether vessel-lining cells change type during this loss, and whether stress from the drugs drives that change.
They read gene activity cell by cell in damaged tissue and found vessel cells with mixed traits. In dish tests, a steroid pushed such cells away from their normal state and hurt new vessel growth. A drug that fights cell stress eased those shifts. In mice, steroids thinned vessels and raised stress, and the same treatment partly protected them.
Catalog record
| CREATOR | Xiaoqiang Yang, Peng Yang, Jiaru Liao, Fan Yang, Mincong He, Ziqi Li, Qiushi Wei, Wei He |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |