Polypeptide sono-adjuvant for ultrasound-activatable regulation of innate immunity and cancer vaccination therapy
Fangmin Chen, Huijuan Zhang, Shiqin Li, Siyuan Ren, Lujia Huang, Yu Guo, Yi Lai, Zhixiong Cai, Xiaolong Liu, Zhiai Xu, Haijun Yu · 2025
Read Polypeptide sono-adjuvant for ultrasound-activatable regulation of innate immunity and cancer vaccination therapy by Fangmin Chen, Huijuan Zhang, Shiqin Li, Siyuan Ren, Lujia Huang, Yu Guo, Yi Lai, Zhixiong Cai, Xiaolong Liu, Zhiai Xu, Haijun Yu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12783111.txt.
Description
Fangmin Chen and co-authors build a sound-activated vaccine helper in 2025. Cancer vaccines need innate immunity fired precisely in lymph nodes, which is hard to control. Their helper is a peptide chain tuned to gather in lymph nodes and stay quiet until ultrasound arrives.
Ultrasound's mechanical and oxidative push opens calcium channels and frees mitochondrial DNA in presenting cells, switching innate paths on. The best helper from their library gave strong, lasting node responses under local ultrasound. Vaccines using it raised antigen-specific T cell responses about threefold over standard helpers. In mouse breast and liver tumors it boosted checkpoint therapy against growth and spread.
Catalog record
| CREATOR | Fangmin Chen, Huijuan Zhang, Shiqin Li, Siyuan Ren, Lujia Huang, Yu Guo, Yi Lai, Zhixiong Cai, Xiaolong Liu, Zhiai Xu, Haijun Yu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |