Evaluating the effect of minimal TIMP variants on protecting and transport across the rat brain microvascular cells (RBMEC)
Elham Taheri, Maryam Raeeszadeh-Sarmazdeh · 2025
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Description
Elham Taheri and Maryam Raeeszadeh-Sarmazdeh test shrunken versions of natural barrier-protecting proteins on rat brain vessel cells. The proteins, called TIMPs, rein in enzymes that chew up tissue scaffolding. One such enzyme, MMP-9, is a chief culprit when the blood-brain barrier leaks in brain disease. Their 2025 study engineers minimal TIMP variants meant to cross the barrier and guard it from both sides.
In cell culture, MMP-9 opened the barrier in proportion to dose, dropping its electrical resistance and letting tracers slip through. Adding natural TIMPs or the two mini variants, mTC1 and mTC3, largely prevented that damage. Stains for the sealing proteins ZO-1 and occludin confirmed the junctions stayed intact. The authors present the mini proteins as tools for studying barrier protection, and as candidates for future brain therapies.
Catalog record
| CREATOR | Elham Taheri, Maryam Raeeszadeh-Sarmazdeh |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |