Loss of SeqA confers low-level fluoroquinolone resistance through transcriptional reprogramming and RpoS dependence in E. coli
Amir Faraz, Nuha Abeer Khan, Deepak Kumar Singh, Hamna Syed, Mohan C Joshi · 2025
Read Loss of SeqA confers low-level fluoroquinolone resistance through transcriptional reprogramming and RpoS dependence in E. coli by Amir Faraz, Nuha Abeer Khan, Deepak Kumar Singh, Hamna Syed, Mohan C Joshi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12782930.txt.
Description
Amir Faraz and co-authors report a surprise in 2025 about a gut germ's grip on its own DNA copying. Losing a protein called SeqA, which helps start and sort DNA copies, slows the germ and scrambles its timing. The team asked if that loss also changes how the germ handles a class of antibiotics that break DNA.
Cells without the protein stood up to those drugs a bit better, needing about half again the dose to die, they found. They stayed as weak as normal to two other drug classes. Glow-tagged sensors showed fewer DNA breaks and a weaker alarm call in the altered cells. Adding the protein back restored normal weakness. The work shows that how a germ packs its DNA can quietly set drug strength.
Catalog record
| CREATOR | Amir Faraz, Nuha Abeer Khan, Deepak Kumar Singh, Hamna Syed, Mohan C Joshi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |