Severe, Resistant Generalized Pustular Psoriasis-Associated Inflammatory Syndrome Successfully Treated With Adalimumab: A Case Report
Evangelos Bourousis, Marina Triantafyllia Kotzamani, Despoina N Maritsi · 2025
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Description
An eight-year-old girl with generalized pustular psoriasis, a rare and severe skin disease marked by fever and sterile pustules, is the subject of this case report. Genetic testing confirmed mutations in the IL36RN and CARD14 genes. Other treatments had failed to hold the disease back. A combination of adalimumab and methotrexate finally brought sustained remission. The authors stress the value of genetic testing in such cases and the promise of biologic drugs for children with this resistant condition.
Catalog record
| CREATOR | Evangelos Bourousis, Marina Triantafyllia Kotzamani, Despoina N Maritsi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |