Cigarette smoke-induced lung-brain barrier dysfunction drives neurocognitive impairment via inflammatory spill-over
Xiao Yu, Hui Xiao, Shilong Bao, Yiding Dong, Zhiyong Dong, Jia Zhao, Guoqiang Wang, Xiaoting Meng, Fang Wang · 2025
Read Cigarette smoke-induced lung-brain barrier dysfunction drives neurocognitive impairment via inflammatory spill-over by Xiao Yu, Hui Xiao, Shilong Bao, Yiding Dong, Zhiyong Dong, Jia Zhao, Guoqiang Wang, Xiaoting Meng, Fang Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12781804.txt.
Description
Yu and eight co-authors trace how cigarette smoke harms both lung and brain barriers. Their 2025 study asks whether leaks in these walls let inflammation spill into the brain. That spill may explain thinking problems in lung disease. Gene data and mouse tests were combined.
Gene checks tied lung disease causally to several brain disorders. Smoke-exposed mice did worse on memory and maze tests. Dye tests showed both barriers had grown leaky. Seal proteins in lung and brain tissue had dropped. Inflammatory signals rose in the blood and brain. The team argues the lung-brain leak path is a target for new care.
Catalog record
| CREATOR | Xiao Yu, Hui Xiao, Shilong Bao, Yiding Dong, Zhiyong Dong, Jia Zhao, Guoqiang Wang, Xiaoting Meng, Fang Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |