Physical activity and myocardial infarction risk: insights from the global burden of disease study 1990–2021 and Mendelian randomization analysis
Yujie Guo, Xianghu Zhao, Wenyuan Xu, Changli Cheng, Lan Lei, Meiqi Zhou, Yikang He · 2025
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Description
Guo and co-authors weigh how low activity shapes heart disease deaths worldwide. They used Global Burden of Disease data from 1990 to 2021. Death rates from heart disease tied to low activity rose over that span. The yearly rise averaged 0.70 percent across the period. The team also ran a genetic test called Mendelian randomization.
The genetic test linked more activity to lower heart attack risk. The odds ratio was 0.17 in their main model. Yet the genetic tools varied a lot, which weakens the estimate. The authors urge wider promotion of daily activity. They also call for larger studies with stronger genetic tools.
Catalog record
| CREATOR | Yujie Guo, Xianghu Zhao, Wenyuan Xu, Changli Cheng, Lan Lei, Meiqi Zhou, Yikang He |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |