Genotoxicity assessment of mesoporous silica and graphene oxide in GDL1 cells
Rikako Ishigamori, Akiko Ohno, Kiyoshi Fukuhara, Shinya Hasegawa, Yukari Totsuka · 2025
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Description
Rikako Ishigamori and co-authors test two nanomaterials for hidden damage to DNA, in a safety study published in 2025. Mesoporous silica and graphene oxide are both spreading through industry, medicine, and cosmetics, yet their gene damaging potential is little mapped. The team exposed a reporter cell line for a day and measured survival plus mutation rates in a marker gene.
Silica cut cell survival dose by dose and raised mutations at its two higher doses. Graphene oxide hurt cells only at high doses, with mutations up in the top group alone. Sequencing showed both materials favored one swap type, and each added its own second signature. The mutation pattern, the authors note, is evidence the materials are truly genotoxic, not just toxic.
Catalog record
| CREATOR | Rikako Ishigamori, Akiko Ohno, Kiyoshi Fukuhara, Shinya Hasegawa, Yukari Totsuka |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |