Warmer temperature accelerates senescence by modifying the aging-dependent changes in the mosquito transcriptome, altering immunity, metabolism, and DNA repair
Lindsay E. Martin, Jordyn S. Barr, Jean-Philippe Cartailler, Shristi Shrestha, Tania Y. Estévez-Lao, Julián F. Hillyer · 2025
Read Warmer temperature accelerates senescence by modifying the aging-dependent changes in the mosquito transcriptome, altering immunity, metabolism, and DNA repair by Lindsay E. Martin, Jordyn S. Barr, Jean-Philippe Cartailler, Shristi Shrestha, Tania Y. Estévez-Lao, Julián F. Hillyer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12781269.txt.
Description
Lindsay Martin and five co-authors study how heat speeds aging in malaria mosquitoes in a 2025 paper. Warmer air raises mosquito body heat, weakens defense against infection, and shortens life. The team ask how heat and age jointly reshape which genes are turned on or off in the African malaria mosquito.
They read gene activity in mosquitoes kept at three warmth levels and at four adult ages, with and without an immune trigger. The youngest adults stood apart from older ones. Heat sped up age linked drops in immune gene activity, but softened age linked shifts in other gene groups tied to energy use and DNA repair.
Catalog record
| CREATOR | Lindsay E. Martin, Jordyn S. Barr, Jean-Philippe Cartailler, Shristi Shrestha, Tania Y. Estévez-Lao, Julián F. Hillyer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |