A prognostic nomogram for colorectal cancer: integrating blood microbiome and clinical factors
Hui Yang, Xiaoli Liu, Dajin Yuan, Huimin Li, Xiaofeng Mu · 2025
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Description
Hui Yang and co-authors build a prediction chart for bowel cancer survival that adds microbes found in blood to the usual clinical signs, in a 2025 paper. Microbes clearly matter in colorectal cancer, but whether those floating in blood say anything about a patient's outlook was unexplored. The team worked with genome and gene-activity data from a large cancer atlas. They distilled the blood microbe data into a single risk score.
A chart, called a nomogram, then merged that score with standard factors such as stage and age. Checks showed the chart predicted survival at one, three, and five years with solid accuracy. The authors also probed why the score works, tracing linked gene patterns and the mix of immune cells around tumours. They present the tool as a step toward prognosis that reads the body's microbial signals too.
Catalog record
| CREATOR | Hui Yang, Xiaoli Liu, Dajin Yuan, Huimin Li, Xiaofeng Mu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |