Non-canonical NOTCH1 signaling regulates ferroptosis vulnerability in dormant lung cancer cells with stable resistance
Hongli Huang, Yihan Chai, Xuewei Wu, Sen Wang, Binglin Li, Yanyan Wang, Wen Zheng, Yuefeng Wu, Di Meng, Hua Wang, Zhengliang Tu, Chengli Du, Xiayi Lyu, Guiying Li, Wei Guo · 2025
Read Non-canonical NOTCH1 signaling regulates ferroptosis vulnerability in dormant lung cancer cells with stable resistance by Hongli Huang, Yihan Chai, Xuewei Wu, Sen Wang, Binglin Li, Yanyan Wang, Wen Zheng, Yuefeng Wu, Di Meng, Hua Wang, Zhengliang Tu, Chengli Du, Xiayi Lyu, Guiying Li, Wei Guo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12780219.txt.
Description
Hongli Huang and co-authors report a 2025 study of a hardy group of lung cancer cells that resist many forms of care. The cells lie dormant, shrug off chemo, targeted drugs, and immune care, and survive paths that kill most tumor cells. The team first pulled this group out of lab lines and patient samples.
A side branch of the NOTCH1 signal path keeps these cells alive, while the main branch stays off. That branch steers cell rest, iron use, shape change, and a form of cell death tied to iron. The work marks the branch as a lever on this hidden, stubborn group.
Catalog record
| CREATOR | Hongli Huang, Yihan Chai, Xuewei Wu, Sen Wang, Binglin Li, Yanyan Wang, Wen Zheng, Yuefeng Wu, Di Meng, Hua Wang, Zhengliang Tu, Chengli Du, Xiayi Lyu, Guiying Li, Wei Guo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |