Macrophage ITGAV is dispensable for post-infarction remodeling in mice and does not mediate fibronectin responses
Ruoshui Li, Shuaibo Huang, Anis Hanna, Silvia C. Hernandez, Akihiko Kubota, Claudio Humeres, Izabela Tuleta, Nikolaos G. Frangogiannis · 2025
Read Macrophage ITGAV is dispensable for post-infarction remodeling in mice and does not mediate fibronectin responses by Ruoshui Li, Shuaibo Huang, Anis Hanna, Silvia C. Hernandez, Akihiko Kubota, Claudio Humeres, Izabela Tuleta, Nikolaos G. Frangogiannis (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12780126.txt.
Description
Eight authors test a macrophage protein's role in heart repair in this 2025 study. After a heart attack, macrophages sense the changed tissue matrix through surface receptors called integrins, and lab work had suggested one of them, ITGAV, steers many macrophage responses.
Using mice lacking the protein only in these immune cells, the team found no real change in post attack remodeling, scarring, vessel growth, or cell recruitment. The protein is nonetheless abundant in infarct macrophages. In dishes, the matrix protein fibronectin strongly reprogrammed macrophage genes, but it did so without needing ITGAV. The careful negative result redirects the search for the receptor that carries those effects.
Catalog record
| CREATOR | Ruoshui Li, Shuaibo Huang, Anis Hanna, Silvia C. Hernandez, Akihiko Kubota, Claudio Humeres, Izabela Tuleta, Nikolaos G. Frangogiannis |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |