ZDHHC14 enhances P16 stability via palmitoylation to inhibit prostate cancer progression
Jian Zhao, Gang Ni, Zhichao Wu, Chunhong Zhang · 2025
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Description
Jian Zhao, Gang Ni, Zhichao Wu, and Chunhong Zhang study how a fat-based tag can stabilize a tumor-blocking protein in prostate cancer. Their study appeared in 2025. The protein, P16, slows the cell cycle and is often weakened in cancer. The team asked whether adding a fatty tag, called palmitoylation, keeps P16 from being destroyed. They traced the tag to one site on the protein and to an enzyme, ZDHHC14, that attaches it.
Raising P16 in prostate cancer cells cut their growth, movement, and invasion. Blocking the tag sped P16's breakdown, while boosting it protected the protein. Removing the enzyme undid that protection. The authors argue the enzyme guards a natural brake on prostate cancer. Strengthening that tag could be a new way to slow the disease.
Catalog record
| CREATOR | Jian Zhao, Gang Ni, Zhichao Wu, Chunhong Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |