Comprehensive analysis of gene signature linking hypoxia and lactylation for predicting prognosis and immunotherapy response in patients with gastric cancer
Ping Liu, Xiaohong Wang, Ruiheng Xie, Rui Luo, Yizhou Wang, Ping Wang, Ruiyu Wang, Xian Zhou, Xiaowei Tang · 2025
Read Comprehensive analysis of gene signature linking hypoxia and lactylation for predicting prognosis and immunotherapy response in patients with gastric cancer by Ping Liu, Xiaohong Wang, Ruiheng Xie, Rui Luo, Yizhou Wang, Ping Wang, Ruiyu Wang, Xian Zhou, Xiaowei Tang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12776241.txt.
Description
Ping Liu and co-authors build a gene signature tying low oxygen and a lactate-linked change to stomach cancer outlook, in a research paper from 2025. Stomach cancer is the world's fifth most common cancer. Inside tumors, low oxygen rewires cell chemistry and piles up lactate, which may shape how the disease grows.
The team mined single-cell and tissue-map data, sorting over one hundred thousand cells into seven types. A statistical method distilled the linked genes into a risk model. They checked the model in an outside cohort and probed immune cell patterns. The signature aims to forecast survival and who may answer immune therapy.
Catalog record
| CREATOR | Ping Liu, Xiaohong Wang, Ruiheng Xie, Rui Luo, Yizhou Wang, Ping Wang, Ruiyu Wang, Xian Zhou, Xiaowei Tang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |