Development and validation of a novel prognostic signature for osteosarcoma
Xiaowei Wang, Xingyu Zhu, Weiwei Li · 2025
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Description
Xiaowei Wang and co-authors build a gene signature that forecasts survival in osteosarcoma, in a 2025 study. This bone cancer strikes mostly teenagers and young adults, spreads readily, and still lacks reliable tools for predicting who will do poorly. The team mined two patient datasets for genes tied to survival and found over a hundred candidates shared by both.
Grouping patients by those genes split the tumors into two clusters with distinct characters. A statistical method then distilled a ten-gene signature that separated high-risk from low-risk patients in validation data. The authors also profiled the immune cells living inside the tumors, since the signature's value may partly reflect the tumor's neighborhood. A validated risk score could help doctors choose who needs heavier therapy and who can be spared it.
Catalog record
| CREATOR | Xiaowei Wang, Xingyu Zhu, Weiwei Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |