Development of a fatty acid metabolism (FAM)-related gene signature for prognosis prediction and personalized therapy in lower grade gliomas
Fangfang Du, Yang Guo, Xiangyu Shi, Xiaomin Liu · 2025
Read Development of a fatty acid metabolism (FAM)-related gene signature for prognosis prediction and personalized therapy in lower grade gliomas by Fangfang Du, Yang Guo, Xiangyu Shi, Xiaomin Liu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12776228.txt.
Description
Fangfang Du, Yang Guo, Xiangyu Shi, and Xiaomin Liu build a four-gene risk score from fat metabolism for lower-grade gliomas. These brain tumors vary so much that outlook and treatment choices stay cloudy. Fat metabolism shifts are tied to tumor start, growth, and spread. Tumor genome data yielded a score built from four fat-linked genes.
High-risk patients died at markedly higher rates than low-risk ones. Their tumors also showed more immune checkpoint gene activity. That pattern hints at a better shot from immune therapy. Drug screens suggest stronger chemo response in the high-risk group as well. Protein checks backed three genes as high in tumors, with the fourth low or absent.
Catalog record
| CREATOR | Fangfang Du, Yang Guo, Xiangyu Shi, Xiaomin Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |