Prognostic chromatin remodeling signature stratifies survival outcomes in lung adenocarcinoma patients
Xiongwei Wang, Yuying Liu, Danhe Huang, Mingyu Yuan, Lianqing Hong · 2025
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Description
Wang and four co-authors built a gene-based risk score in twenty twenty-five to sort lung adenocarcinoma patients by outlook. This common lung cancer kills many people worldwide, and genes that remodel chromatin, the packaging of DNA, help drive it.
Using large public datasets, the team first split patients into three groups by those genes' activity, each with its own survival pattern. They then distilled a score from nineteen genes that divides patients into high and low risk. High-risk patients lived shorter lives and answered differently to chemotherapy drugs. The score also hinted at who might benefit from immune therapy. In lab tests, silencing one highlighted gene slowed the cancer cells' harmful behavior. The authors package the score into a chart that doctors could use at the bedside. They offer it as a step toward care fitted to each patient.
Catalog record
| CREATOR | Xiongwei Wang, Yuying Liu, Danhe Huang, Mingyu Yuan, Lianqing Hong |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |