Development and validation of a novel palmitoylation-related prognostic signature in head and neck squamous cell carcinoma
Meredith Nuo Zhang, Hongcun Bao, Xiang Ji · 2025
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Description
Meredith Nuo Zhang, Hongcun Bao, and Xiang Ji build a prognostic signature from palmitoylation-related genes for head and neck cancer, published in 2025. Palmitoylation is a reversible lipid modification that guides protein movement and signaling, and it has been linked to several cancers. Its role in this aggressive, varied cancer was largely unexplored.
Using cancer atlas and public data sets as training and validation cohorts, the team curated thousands of related genes and found hundreds that differed in tumors. Statistical selection narrowed these to an eight-gene risk model. They combined the risk score with clinical factors in a prediction chart. Survival curves, accuracy analyses, immune profiling, and drug sensitivity tests were used to judge the model's clinical value for sorting patients by risk.
Catalog record
| CREATOR | Meredith Nuo Zhang, Hongcun Bao, Xiang Ji |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |