Targeted next-generation sequencing reveals genomic differences between male and female breast cancer
Jiyuan Zhu, Shanshan Xu, Wei Hua, Mengdi Wang, Shichao Zhang, Pengtian Lu, He Wu · 2025
Read Targeted next-generation sequencing reveals genomic differences between male and female breast cancer by Jiyuan Zhu, Shanshan Xu, Wei Hua, Mengdi Wang, Shichao Zhang, Pengtian Lu, He Wu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12776197.txt.
Description
Jiyuan Zhu and co-authors compare the gene changes in breast cancer between men and women in a 2025 study. Male breast cancer is rare, often caught late, and treated by rules borrowed from the far more common female disease.
Tumor samples from twelve men and fourteen women went through targeted gene sequencing. Some mutated genes were shared, but the patterns differed. One gene's mutation rate differed sharply between the sexes, and two genes often gained extra copies in women yet never in men. Women's tumors carried more mutations overall. The men's private gene changes clustered in growth signaling pathways. The authors say the differences justify studying the male disease on its own terms.
Catalog record
| CREATOR | Jiyuan Zhu, Shanshan Xu, Wei Hua, Mengdi Wang, Shichao Zhang, Pengtian Lu, He Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |