O-GlcNAcylation levels predict radiotherapy outcome in non-small cell lung cancer
Xiaoliang Wang, Yujiao Ma, Ying Dong, Yanling Wang, Jupeng Yuan, Jinming Yu, Dawei Chen · 2025
Read O-GlcNAcylation levels predict radiotherapy outcome in non-small cell lung cancer by Xiaoliang Wang, Yujiao Ma, Ying Dong, Yanling Wang, Jupeng Yuan, Jinming Yu, Dawei Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12775701.txt.
Description
Xiaoliang Wang and six co-authors test a protein mark as a guide to radiotherapy results in lung cancer in a 2025 study. The mark, called O-GlcNAcylation, is a sugar tag placed on proteins, tied to how cells use glucose. Little was known about whether its level in a tumor forecasts how well radiation works.
The team reviewed 216 patients with non-small cell lung cancer who had radiation and imaging scans. Tumors with low levels of the mark answered treatment poorly and came back sooner, and those patients lived shorter lives. Blood sugar and tumor sugar uptake on scans did not forecast treatment response. The authors present the mark as a useful sign for judging likely benefit.
Catalog record
| CREATOR | Xiaoliang Wang, Yujiao Ma, Ying Dong, Yanling Wang, Jupeng Yuan, Jinming Yu, Dawei Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |