A single-cell atlas reveals the tumorigenesis and microenvironment status of primary tracheobronchial tumors
Chen Shu, Xiyang Tang, Kaifu Zheng, Runze Zhang, Yulong Zhou, Mengchao Li, Weiguang Du, Yuquan Bai, Yang Shen, Yujian Liu, Haitang Yang, Feng Yao, Xiaolong Yan, Nan Ma, Jinbo Zhao · 2025
Read A single-cell atlas reveals the tumorigenesis and microenvironment status of primary tracheobronchial tumors by Chen Shu, Xiyang Tang, Kaifu Zheng, Runze Zhang, Yulong Zhou, Mengchao Li, Weiguang Du, Yuquan Bai, Yang Shen, Yujian Liu, Haitang Yang, Feng Yao, Xiaolong Yan, Nan Ma, Jinbo Zhao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12775392.txt.
Description
Chen Shu and a large team of co-authors built a single-cell atlas of rare tumors of the windpipe and main airways, in this 2025 study. These tumors can often be removed by surgery, but advanced cases need better options. A cell-level map of the tumors and their surroundings could point to new targets.
The team read genes cell by cell in 52,739 cells from tumor samples. The three tumor kinds differed in their support cells, and one kind, classed as benign, was rich in stirred-up immune cells. A small cell group marked by one gene appeared in two cancer kinds and looked stem-like. Signals between tumor cells and killer T cells stood out as well. Staining tests confirmed the map's main cell groups. The authors offer the atlas as a base for better diagnosis and treatment.
Catalog record
| CREATOR | Chen Shu, Xiyang Tang, Kaifu Zheng, Runze Zhang, Yulong Zhou, Mengchao Li, Weiguang Du, Yuquan Bai, Yang Shen, Yujian Liu, Haitang Yang, Feng Yao, Xiaolong Yan, Nan Ma, Jinbo Zhao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |