Immunoregulatory roles of post-translational modifications in colorectal cancer: mechanisms and therapeutic implications
Xinyue Liang, Jinhong Yao, Wenbo Jiao, Xiaolin Li, Bo Yang, Hongqiong Fan · 2025
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Description
Xinyue Liang and co-authors review protein edits that steer immunity in bowel cancer in a 2025 paper. Colorectal tumors dodge immune attack, which blunts modern immunotherapy. After a protein is built, small chemical edits steer its job and lifespan. Those edits shape how tumors show themselves, draw immune cells in, and set checkpoint brakes.
The review traces how edits feed T cell wear out, macrophage tilt, and suppressive signal webs inside the tumor. Edits also sway reply to checkpoint drugs and cell therapies. Drug plans that aim at the edit machinery may lift antitumor immunity. New omics tools speed the hunt for edit based marks and targets.
Catalog record
| CREATOR | Xinyue Liang, Jinhong Yao, Wenbo Jiao, Xiaolin Li, Bo Yang, Hongqiong Fan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |