Circulating exosomal miR-20b-5p and miR-1273g-3p were potential biomarkers for diagnosis and prognosis of acute coronary syndrome
Ruiqiang Weng, Xia Li, Junli Zhao, Xiaodong Gu, Sudong Liu · 2025
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Description
Ruiqiang Weng and four co-authors published a 2025 study of two tiny RNA molecules carried in blood vesicles as markers for acute coronary syndrome. The team compared 138 patients with the syndrome against 129 controls with clean coronary arteries, measuring the two RNAs in plasma exosomes. Both ran markedly higher in patients. Each alone predicted the syndrome modestly, below the standard troponin test.
Paired with troponin, the RNAs improved prediction clearly. During a year of follow-up after stent procedures, patients with high levels of one RNA, miR-20b-5p, suffered more major heart events. That RNA stayed linked to events after full adjustment, with a hazard ratio near 3.1. The authors present the pair as diagnostic aids and the one RNA as a prognostic signal.
Catalog record
| CREATOR | Ruiqiang Weng, Xia Li, Junli Zhao, Xiaodong Gu, Sudong Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |