Human monoclonal antibodies that target clade 2.3.4.4b H5N1 hemagglutinin
Garazi Peña Alzua, André Nicolás León, Temima Yellin, Disha Bhavsar, Madhumathi Loganathan, Kaitlyn Bushfield, Philip J. M. Brouwer, Alesandra J. Rodriguez, Trushar Jeevan, Richard Webby, Christine Marizzi, Julianna Han, Andrew B. Ward, J. Andrew Duty, Florian Krammer · 2025
Read Human monoclonal antibodies that target clade 2.3.4.4b H5N1 hemagglutinin by Garazi Peña Alzua, André Nicolás León, Temima Yellin, Disha Bhavsar, Madhumathi Loganathan, Kaitlyn Bushfield, Philip J. M. Brouwer, Alesandra J. Rodriguez, Trushar Jeevan, Richard Webby, Christine Marizzi, Julianna Han, Andrew B. Ward, J. Andrew Duty, Florian Krammer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12775146.txt.
Description
Garazi Peña Alzua and colleagues published a 2025 study creating human antibodies against the H5N1 bird flu virus now spreading worldwide. The virus has killed many wild and farmed birds and infected mammals, raising fears of a human pandemic. The researchers targeted the protein the virus uses to enter cells.
Special mice carrying human antibody genes were immunized, yielding sixteen fully human antibodies. Most recognized several variants of the virus, and nearly all neutralized it in laboratory tests. The strongest ones also protected mice when given before or after infection. Such antibodies could become treatments or emergency protection if the virus adapts to people.
Catalog record
| CREATOR | Garazi Peña Alzua, André Nicolás León, Temima Yellin, Disha Bhavsar, Madhumathi Loganathan, Kaitlyn Bushfield, Philip J. M. Brouwer, Alesandra J. Rodriguez, Trushar Jeevan, Richard Webby, Christine Marizzi, Julianna Han, Andrew B. Ward, J. Andrew Duty, Florian Krammer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |