Investigation of image-guided in vivo irradiation on voiding patterns and bladder contractility in female mice
Sarah McDowell, Conor Breen, Niamh McKerr, Kirtiman Srivastava, Daniel Crummey, Mihaela Ghita-Pettigrew, Karl T Butterworth, Joe M O’Sullivan, Kevin M Prise, Karen D McCloskey · 2025
Read Investigation of image-guided in vivo irradiation on voiding patterns and bladder contractility in female mice by Sarah McDowell, Conor Breen, Niamh McKerr, Kirtiman Srivastava, Daniel Crummey, Mihaela Ghita-Pettigrew, Karl T Butterworth, Joe M O’Sullivan, Kevin M Prise, Karen D McCloskey (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12775023.txt.
Description
Sarah McDowell and co-authors present a 2025 animal study on how radiation therapy affects the bladder. Pelvic radiotherapy often leaves patients with urinary symptoms. Image-guided irradiation in mice lets researchers study the bladder's response under controlled conditions that mimic the clinic.
Female mice received a single 20-gray dose aimed at the bladder under CT guidance. Urination patterns were tracked with void spot tests before and after. Bladder strips were also tested for squeeze strength in the lab. About half the mice showed more void spots and smaller volumes in the weeks after treatment. Nerve-driven contractions weakened at two weeks, then partly recovered over months. The model gives a baseline for testing protective drugs.
Catalog record
| CREATOR | Sarah McDowell, Conor Breen, Niamh McKerr, Kirtiman Srivastava, Daniel Crummey, Mihaela Ghita-Pettigrew, Karl T Butterworth, Joe M O’Sullivan, Kevin M Prise, Karen D McCloskey |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |