S-allyl cysteine and alliin enhance catalase activity and prevent aggregation to counter oxidative stress in alzheimer’s disease
Seemasundari Yumlembam, Kuldeep Singh, Akshita Gupta, Priya Adhikarimayum, Anju Kumari, Kananbala Sarangthem, Laishram Rajendrakumar Singh · 2025
Read S-allyl cysteine and alliin enhance catalase activity and prevent aggregation to counter oxidative stress in alzheimer’s disease by Seemasundari Yumlembam, Kuldeep Singh, Akshita Gupta, Priya Adhikarimayum, Anju Kumari, Kananbala Sarangthem, Laishram Rajendrakumar Singh (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12774959.txt.
Description
Seemasundari Yumlembam and co-authors test two garlic compounds in this 2025 study of Alzheimer's disease. Harm from oxygen stress drives much of the disease, and a guard enzyme that fights that stress runs weak in patients. The enzyme also clumps into the plaques that mark the disease.
Both garlic compounds raised the enzyme's activity in lab tests, more at higher doses. Computer models show the pair grip the enzyme at a side site and pack its shape tighter. That tighter shape held up better under heat. The compounds also cut the enzyme's urge to form harmful clumps. The authors name the pair as natural leads worth more study.
Catalog record
| CREATOR | Seemasundari Yumlembam, Kuldeep Singh, Akshita Gupta, Priya Adhikarimayum, Anju Kumari, Kananbala Sarangthem, Laishram Rajendrakumar Singh |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |