Diminished osteoprotegerin production by gingival fibroblasts from periodontitis patients is associated with their reduced ability to suppress osteoclastogenesis
Elwira Nieboga, Kamila Drzazga, Alicja Plonczynska, Dominika M. Drapala, Aureliusz Schuster, Mariia Melnykova, Julia Skawska, Michal Zajdel, Malgorzata Kantorowicz, Sanne Roffel, Joanna Cichy, Marta Czesnikiewicz-Guzik, Tomasz Kaczmarzyk, Susan Gibbs, Jan Potempa, Aleksander M. Grabiec · 2025
Read Diminished osteoprotegerin production by gingival fibroblasts from periodontitis patients is associated with their reduced ability to suppress osteoclastogenesis by Elwira Nieboga, Kamila Drzazga, Alicja Plonczynska, Dominika M. Drapala, Aureliusz Schuster, Mariia Melnykova, Julia Skawska, Michal Zajdel, Malgorzata Kantorowicz, Sanne Roffel, Joanna Cichy, Marta Czesnikiewicz-Guzik, Tomasz Kaczmarzyk, Susan Gibbs, Jan Potempa, Aleksander M. Grabiec (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12774911.txt.
Description
Elwira Nieboga and co-authors show why gum cells from diseased mouths fail to protect jawbone, in a 2025 study. In periodontitis, bone-eating cells called osteoclasts dissolve the bone that holds teeth. Healthy gum fibroblasts normally release a brake molecule, osteoprotegerin, that holds those cells back. The team compared fluid from healthy and diseased donors' gum cells.
Healthy cell fluid strongly suppressed osteoclast formation and was rich in the brake molecule. A lab-grown gum model confirmed fibroblasts as its main source. Cells from patients made far less of it and suppressed osteoclasts weakly. Silencing the molecule's gene in patient cells weakened the brake further. The deficit helps explain the runaway bone loss of gum disease.
Catalog record
| CREATOR | Elwira Nieboga, Kamila Drzazga, Alicja Plonczynska, Dominika M. Drapala, Aureliusz Schuster, Mariia Melnykova, Julia Skawska, Michal Zajdel, Malgorzata Kantorowicz, Sanne Roffel, Joanna Cichy, Marta Czesnikiewicz-Guzik, Tomasz Kaczmarzyk, Susan Gibbs, Jan Potempa, Aleksander M. Grabiec |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |