A lignan compound regulates LPS modifications via PmrA/B signaling cascades to potentiate colistin efficacy in vivo
Qiuyue Diao, Zixing Zhong, Qin Zhong, Yidan Cao, Xiaona Fan, Yujiao Liang, Huihui Zhang, Zehua Cui, Xinlei Lian, Xiaoping Liao, Donghao Zhao, Jian Sun, Hao Ren · 2025
Read A lignan compound regulates LPS modifications via PmrA/B signaling cascades to potentiate colistin efficacy in vivo by Qiuyue Diao, Zixing Zhong, Qin Zhong, Yidan Cao, Xiaona Fan, Yujiao Liang, Huihui Zhang, Zehua Cui, Xinlei Lian, Xiaoping Liao, Donghao Zhao, Jian Sun, Hao Ren (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12774351.txt.
Description
Qiuyue Diao and a team of co-authors show how a plant compound revives a last-line antibiotic, in a paper dated twenty twenty-five. The compound is magnolol, a lignan, and the drug is colistin. Together they wipe out tough Gram-negative bacteria and slow resistance growth.
Magnolol breaks a two-part signal system that guards the bacterial coat. With that guard off, the coat loses charge and colistin binds far better. The drug then punches ring-shaped holes that leak the cell to death. The work names silencing that signal as a sound plan to rescue colistin.
Catalog record
| CREATOR | Qiuyue Diao, Zixing Zhong, Qin Zhong, Yidan Cao, Xiaona Fan, Yujiao Liang, Huihui Zhang, Zehua Cui, Xinlei Lian, Xiaoping Liao, Donghao Zhao, Jian Sun, Hao Ren |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |