UBQLN2 is necessary for UBE3A-mediated proteasomal degradation of the domesticated retroelement PEG10
Julia E Roberts, Phuoc T Huynh, Luis O Carale, Alexandra M Whiteley · 2025
Read UBQLN2 is necessary for UBE3A-mediated proteasomal degradation of the domesticated retroelement PEG10 by Julia E Roberts, Phuoc T Huynh, Luis O Carale, Alexandra M Whiteley (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12772957.txt.
Description
Julia Roberts and co-authors pin down how a virus-like protein is destroyed inside cells, in this 2025 study. The protein, PEG10, descends from an ancient retrovirus now built into our genome. It comes in two forms, and only the longer form depends on a shuttle protein called UBQLN2 for disposal.
Both forms grip the shuttle, but only the long form is tagged and sent to the cell's shredder, the proteasome. Mutating key spots in its tail removed the tag and blocked disposal. A tagging enzyme, UBE3A, proved necessary as well, and it needs the shuttle to do its work. The findings clarify how shuttle proteins choose their cargo.
Catalog record
| CREATOR | Julia E Roberts, Phuoc T Huynh, Luis O Carale, Alexandra M Whiteley |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |