Antibiotic-induced microbiota depletion impairs the proregenerative response to a biological scaffold
Natalie Rutkowski, Brenda Yang, Elise Gray-Gaillard, Anna Ruta, Joscelyn C. Mejías, Michael Patatanian, Christopher Cherry, Nazmiye Celik, Katlin B. Stivers, Shri Ramanujam, Nathan L. Price, Franck Housseau, Drew M. Pardoll, Cynthia L. Sears, Jennifer H. Elisseeff · 2025
Read Antibiotic-induced microbiota depletion impairs the proregenerative response to a biological scaffold by Natalie Rutkowski, Brenda Yang, Elise Gray-Gaillard, Anna Ruta, Joscelyn C. Mejías, Michael Patatanian, Christopher Cherry, Nazmiye Celik, Katlin B. Stivers, Shri Ramanujam, Nathan L. Price, Franck Housseau, Drew M. Pardoll, Cynthia L. Sears, Jennifer H. Elisseeff (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12772165.txt.
Description
Healing scaffolds made from animal tissue help wounds repair by stirring a type 2 immune response, but gut microbes may sway that response. Natalie Rutkowski and co-authors test the link both ways in this 2025 mouse study. Germ-free mice given normal gut microbes showed shifts in those microbes after a scaffold implant, while mice drained of microbes by antibiotics healed differently.
Six weeks after implant, the microbe-depleted mice had fewer young muscle cells and more scar-linked gene activity. Key repair players dropped too: eosinophils, repair-type macrophages, and T cells making interleukin-4. Scaffold implants also reshaped the gut community itself, mainly in amino acid pathways. The findings tie gut health to how well repair scaffolds work.
Catalog record
| CREATOR | Natalie Rutkowski, Brenda Yang, Elise Gray-Gaillard, Anna Ruta, Joscelyn C. Mejías, Michael Patatanian, Christopher Cherry, Nazmiye Celik, Katlin B. Stivers, Shri Ramanujam, Nathan L. Price, Franck Housseau, Drew M. Pardoll, Cynthia L. Sears, Jennifer H. Elisseeff |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |