A systematic scoring system to optimise the testing of neurotherapeutics in models of perinatal brain injury, with an applied case study of human umbilical-cord MSC
Cindy Bokobza, Clémence Réda, Syam Nair, David Guenoun, Eridan Rocha-Ferreira, Valérie Faivre, Tifenn Le Charpentier, Cora Nijboer, Caroline de Theije, Sophie Lebon, Joakim Ek, Mohamed Gaeth Hafez, Leslie Schwendimann, Médine Benchouaia, Sophie Lemoine, Giorgia Volpi, Katiuscia Dallaglio, Nicola Pel · 2025
Read A systematic scoring system to optimise the testing of neurotherapeutics in models of perinatal brain injury, with an applied case study of human umbilical-cord MSC by Cindy Bokobza, Clémence Réda, Syam Nair, David Guenoun, Eridan Rocha-Ferreira, Valérie Faivre, Tifenn Le Charpentier, Cora Nijboer, Caroline de Theije, Sophie Lebon, Joakim Ek, Mohamed Gaeth Hafez, Leslie Schwendimann, Médine Benchouaia, Sophie Lemoine, Giorgia Volpi, Katiuscia Dallaglio, Nicola Pel (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12772108.txt.
Description
Cindy Bokobza and co-authors build a scoring system to pick brain therapies for preterm babies in two thousand twenty-five. Over fifteen million babies are born early each year, and up to three in five face later nerve disorders. Testing candidate drugs in animals is slow and pricey, with few winners.
Their system grades therapies in a set, repeatable way across dose, timing, and route. It fuses deep gene data, computing, and injury models of the preterm brain. A case study runs the pipeline on stem cells drawn from human umbilical cords. The scoring picks the best dose and schedule before costly trials. The authors offer the frame to sharpen preclinical testing across the field.
Catalog record
| CREATOR | Cindy Bokobza, Clémence Réda, Syam Nair, David Guenoun, Eridan Rocha-Ferreira, Valérie Faivre, Tifenn Le Charpentier, Cora Nijboer, Caroline de Theije, Sophie Lebon, Joakim Ek, Mohamed Gaeth Hafez, Leslie Schwendimann, Médine Benchouaia, Sophie Lemoine, Giorgia Volpi, Katiuscia Dallaglio, Nicola Pel |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |