Dual block evidence of the effects of topiramate, a sulfamate-substituted monosaccharide, on voltage-gated sodium current and hyperpolarization-activated cation current
Ray-Chang Tzeng, Ming-Chi Lai, Sheng-Nan Wu, Chin-Wei Huang · 2025
Read Dual block evidence of the effects of topiramate, a sulfamate-substituted monosaccharide, on voltage-gated sodium current and hyperpolarization-activated cation current by Ray-Chang Tzeng, Ming-Chi Lai, Sheng-Nan Wu, Chin-Wei Huang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12771823.txt.
Description
Ray-Chang Tzeng and three co-authors test a known seizure drug in lab cells in a 2025 study of electric currents in cell walls. The drug, topiramate, is used for seizures, nerve pain, and migraine, but its exact effects on cell currents were not fully clear. The team used fine glass tools to clamp onto cells and record the currents directly.
They worked with hormone-making cells grown in the lab. The drug blocked two forms of the sodium current, both the brief pulse and the late tail, more strongly as the dose rose. It also blocked a second current that is switched on when the cell voltage drops. The dual block helps explain how the drug calms overactive cells.
Catalog record
| CREATOR | Ray-Chang Tzeng, Ming-Chi Lai, Sheng-Nan Wu, Chin-Wei Huang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |