Unveiling the ITGβ1-CLIC1 axis: a new frontier in oral squamous cell carcinoma progression and immune evasion: insights from the tumor-mimetic ECM system
Yungang He, Renjie Shuai, Jian Wu, Lian Zhou · 2025
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Description
Yungang He and co-authors study a protein pair in oral squamous cell carcinoma in work from 2025. The cancer interacts with its surrounding matrix and immune environment as it grows and spreads.
Database and tissue analyses showed both integrin beta 1 and its partner CLIC1 raised in tumors, linked to worse outlook. In a lab system that mimics tumor matrix, raising the integrin boosted cell growth, movement, and invasion. Blocking it lowered the partner protein. The pair also correlated with patterns of immune cell entry, hinting at a role in immune evasion.
Catalog record
| CREATOR | Yungang He, Renjie Shuai, Jian Wu, Lian Zhou |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |