Urothelial genotoxicity of household chemicals in healthy canine urinary bladder organoids relative to observed urinary exposures in pet dogs
Hannah M. Peterson, Christopher Zdyrski, Karin Allenspach, Jonathan P. Mochel, Lauren A. Trepanier · 2025
Read Urothelial genotoxicity of household chemicals in healthy canine urinary bladder organoids relative to observed urinary exposures in pet dogs by Hannah M. Peterson, Christopher Zdyrski, Karin Allenspach, Jonathan P. Mochel, Lauren A. Trepanier (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12771537.txt.
Description
Hannah Peterson and co-authors test household chemicals on dog bladder tissue in a 2025 study. Bladder cancer in pet dogs mirrors the invasive human disease, and home chemicals are prime suspects. The question is whether the doses dogs truly pass in urine can damage DNA.
Bladder organoids grown from healthy dogs set the damage thresholds for three chemicals. Acrolein, arsenic, and one industrial amine were dosed onto the mini-tissues. A comet assay measured DNA breaks, with and without an enzyme that exposes hidden lesions. Real urine levels from dogs with and without cancer were then compared. A lab threshold tied to real exposure sharpens blame and safety alike.
Catalog record
| CREATOR | Hannah M. Peterson, Christopher Zdyrski, Karin Allenspach, Jonathan P. Mochel, Lauren A. Trepanier |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |