Analysis of the therapeutic effect of allogeneic hematopoietic stem cell transplantation in the treatment of pediatric acute lymphoblastic leukemia with E2A::HLF fusion gene: a case series
Yuanfang Jing, Ang Wei, Chenguang Jia, Jun Yang, Guanghua Zhu, Yanhui Luo, Kaige Zhang, Wei Yang, Wei Chen, Meng Zhang, Maoquan Qin, Bin Wang · 2025
Read Analysis of the therapeutic effect of allogeneic hematopoietic stem cell transplantation in the treatment of pediatric acute lymphoblastic leukemia with E2A::HLF fusion gene: a case series by Yuanfang Jing, Ang Wei, Chenguang Jia, Jun Yang, Guanghua Zhu, Yanhui Luo, Kaige Zhang, Wei Yang, Wei Chen, Meng Zhang, Maoquan Qin, Bin Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12771198.txt.
Description
Jing and co-authors review four children with a rare, stubborn form of blood cancer marked by a fused gene called E2A::HLF. Fewer than one in a hundred childhood cases carry the fusion, mostly in older children, and outcomes stay poor even after stem cell transplant. All four children first received a high-risk chemotherapy plan at a Chinese center.
Two children who never reached remission got engineered immune cell therapy, and all four reached full remission before transplant. One child died of transplant complications, and one relapsed and died despite later cell therapy. Two children given donor cell boosts after transplant remain alive. The authors suggest pairing cell therapy before transplant with donor boosts after may help this subgroup.
Catalog record
| CREATOR | Yuanfang Jing, Ang Wei, Chenguang Jia, Jun Yang, Guanghua Zhu, Yanhui Luo, Kaige Zhang, Wei Yang, Wei Chen, Meng Zhang, Maoquan Qin, Bin Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |