The characteristics of pulmonary fibrosis in a neonatal rat model of chronic hyperoxia lung injury
Hanyu Wu, Wei Shen, Chao Chen, Lin Yuan · 2025
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Description
Hanyu Wu, Wei Shen, Chao Chen, and Lin Yuan track lung scarring in newborn rats exposed to high oxygen, in a 2025 paper. Premature babies often get a lung disease where scarring goes on to harm lung function for years. The team asks how the traits of that scarring change over time.
Newborn rats breathed room air or high oxygen and were sampled at six ages up to six weeks. By day fourteen the high oxygen group showed fewer air sacs, wider spaces, and more collagen. Key cell markers fell while a scar linked protein rose. Collagen kept building and peaked at the last check. The time line can guide when care might best slow the scarring.
Catalog record
| CREATOR | Hanyu Wu, Wei Shen, Chao Chen, Lin Yuan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |