The PIK3CA/AKT pathway drives therapy resistance in rhabdomyosarcoma
Qiqi Yang, Yueyang Wang, Luis A Corchete Sanchez, Sabateeshan Mathavarajah, Qian Qin, Yun Wei, Eric Alpert, Lauren Whelton, Priyanshu Sharma, Stephanie Strom, Ilyas Oultache, A John Iafrate, Luca Pinello, Esther Rheinbay, Chuan Yan, David M Langenau · 2025
Read The PIK3CA/AKT pathway drives therapy resistance in rhabdomyosarcoma by Qiqi Yang, Yueyang Wang, Luis A Corchete Sanchez, Sabateeshan Mathavarajah, Qian Qin, Yun Wei, Eric Alpert, Lauren Whelton, Priyanshu Sharma, Stephanie Strom, Ilyas Oultache, A John Iafrate, Luca Pinello, Esther Rheinbay, Chuan Yan, David M Langenau (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12770561.txt.
Description
Qiqi Yang and colleagues studied drug resistance in a childhood muscle cancer in 2025. The cancer is called rhabdomyosarcoma. A two-drug pairing is now in clinical trials for it. Resistance to that pairing has appeared in other cancers. The team grew human tumors in mice and treated them. The pairing shrank tumors at first. Over half later resisted treatment and grew again. Resistant tumors changed gene activity without new shared mutations.
Most resistant models switched on one growth pathway. That pathway woke a stress protein and its target genes. Those genes build pumps that push drugs out of cells. A drug blocking the pathway made resistant cells sensitive again. The triple pairing also killed cells that resisted standard chemotherapy. It curbed tumor growth in the mouse models too. The authors name this pathway as a common escape route. They propose blocking it as a strategy against resistant disease.
Catalog record
| CREATOR | Qiqi Yang, Yueyang Wang, Luis A Corchete Sanchez, Sabateeshan Mathavarajah, Qian Qin, Yun Wei, Eric Alpert, Lauren Whelton, Priyanshu Sharma, Stephanie Strom, Ilyas Oultache, A John Iafrate, Luca Pinello, Esther Rheinbay, Chuan Yan, David M Langenau |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |