Aberrant adenosine A2A receptor signaling in the choroid plexus drives CSF hypersecretion and ventriculomegaly in hydrocephalus
Wu Zheng, Lanxin Hu, Yuwen Yang, Xuhang Li, Jia Wu, Wangchao Chen, Yiwei Jiang, Yuhan Chen, Hongcai Wang, Shiwei Li, Kuan Feng, Cheng Zheng, Yanjiang Wang, Rodrigo A. Cunha, Zhongyue Lv, Jiang-Fan Chen · 2025
Read Aberrant adenosine A2A receptor signaling in the choroid plexus drives CSF hypersecretion and ventriculomegaly in hydrocephalus by Wu Zheng, Lanxin Hu, Yuwen Yang, Xuhang Li, Jia Wu, Wangchao Chen, Yiwei Jiang, Yuhan Chen, Hongcai Wang, Shiwei Li, Kuan Feng, Cheng Zheng, Yanjiang Wang, Rodrigo A. Cunha, Zhongyue Lv, Jiang-Fan Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12770498.txt.
Description
Wu Zheng and fifteen co-authors find a fluid switch behind brain water buildup in a 2025 study. The state, hydrocephalus, jams the brain's fluid flow and has no sound drug care. A brain signal named adenosine was found high in patients' fluid, and its dock ran dense in the fluid-making tissue.
Dosing the signal for two weeks, or breeding mice with extra docks there, drove excess fluid and swollen chambers. Blocking the dock path cut the flow back. The switch is thus a drug aim. A long drug-free ill gains a lead.
Catalog record
| CREATOR | Wu Zheng, Lanxin Hu, Yuwen Yang, Xuhang Li, Jia Wu, Wangchao Chen, Yiwei Jiang, Yuhan Chen, Hongcai Wang, Shiwei Li, Kuan Feng, Cheng Zheng, Yanjiang Wang, Rodrigo A. Cunha, Zhongyue Lv, Jiang-Fan Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |