Insights into de-mixing and morphology modulation in coacervate-membrane interactions from integrating experiments and simulations
Sayantan Mondal, Agustín Mangiarotti, Rumiana Dimova, Qiang Cui · 2025
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Description
Sayantan Mondal, Agustín Mangiarotti, Rumiana Dimova, and Qiang Cui study how protein droplets reshape cell-like membranes in a paper from two thousand twenty-five. Disordered proteins can condense into droplets that stick to membranes and bend them. The details of that touching interface were incomplete.
Using microscopy, light-based chemistry probes, and two simulation styles, the team watched a simple droplet pair meet artificial membranes. Stickiness could be tuned by the membrane's charged lipid share, and a contact angle measured it in both lab and computer. The membrane under the droplet flowed about half as fast, because lipids crowded there and packed tighter. Local lipid sorting also appeared where droplet met membrane. The framework joins experiment and simulation cleanly.
Catalog record
| CREATOR | Sayantan Mondal, Agustín Mangiarotti, Rumiana Dimova, Qiang Cui |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |