A novel diagnosis strategy for chronic inflammatory bowel diseases using immuno-PET of [89Zr]Zr-IL-23p19 antibody
Nare Ko, Jung Won Ahn, Dong Yun Lee, Jin Hwa Chung, Seung Jun Oh, Hyori Kim, Young Pil Kim, Seog-Young Kim, Sang Ju Lee · 2025
Read A novel diagnosis strategy for chronic inflammatory bowel diseases using immuno-PET of [89Zr]Zr-IL-23p19 antibody by Nare Ko, Jung Won Ahn, Dong Yun Lee, Jin Hwa Chung, Seung Jun Oh, Hyori Kim, Young Pil Kim, Seog-Young Kim, Sang Ju Lee (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12770407.txt.
Description
Judging gut inflammation today means symptom scores and scopes, both blunt at the disease's mild beginnings. Nare Ko and eight co-authors test a smarter tracer in this 2025 study: an antibody aimed at IL-23p19, a driver of bowel inflammation, tagged with a long-lived radioactive label for PET imaging. Mice with chemically inflamed colons received the tracer.
Scans lit up exactly the inflamed stretches, matching the microscope's verdict and the protein's own distribution. A standard metabolic tracer, by contrast, glowed diffusely everywhere. The new tracer's uptake rose and fell with clinical severity scores, while the old tracer's barely tracked them. Chemistry checks showed the labeled antibody stayed pure and stable. The authors present the method as a candidate for spotting early inflammation and following treatment without repeated scopes.
Catalog record
| CREATOR | Nare Ko, Jung Won Ahn, Dong Yun Lee, Jin Hwa Chung, Seung Jun Oh, Hyori Kim, Young Pil Kim, Seog-Young Kim, Sang Ju Lee |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |