An ultrapotent human antibody neutralizes all maturation states of Zika virus
Bo Shu, Thiam-Seng Ng, Xin-Ni Lim, Shuijun Zhang, Victor A. Kostyuchenko, Guntur Fibriansah, Benjamin D. McElvany, Valerie Shyn-Yun Chew, Aravinda M. de Silva, Sean A. Diehl, Shee-Mei Lok · 2025
Read An ultrapotent human antibody neutralizes all maturation states of Zika virus by Bo Shu, Thiam-Seng Ng, Xin-Ni Lim, Shuijun Zhang, Victor A. Kostyuchenko, Guntur Fibriansah, Benjamin D. McElvany, Valerie Shyn-Yun Chew, Aravinda M. de Silva, Sean A. Diehl, Shee-Mei Lok (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12768462.txt.
Description
Bo Shu and co-authors solve how a human antibody disarms Zika virus in all its forms. Their twenty twenty-five paper targets a virus that harms unborn babies and still lacks a vaccine or cure. Infected cells release both mature and immature particles, and both can infect.
Frozen electron images show the antibody A9E gripping one envelope protein across both forms. It blocks the virus before or during cell entry, clumping and warping particles. Immature forms, often shrugged off, proved especially well covered here. A single antibody that handles every maturation state is a strong lead for therapy design and for vaccine makers choosing targets.
Catalog record
| CREATOR | Bo Shu, Thiam-Seng Ng, Xin-Ni Lim, Shuijun Zhang, Victor A. Kostyuchenko, Guntur Fibriansah, Benjamin D. McElvany, Valerie Shyn-Yun Chew, Aravinda M. de Silva, Sean A. Diehl, Shee-Mei Lok |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |