Amplicon-based DNA sequencing to characterize Duffy antigen polymorphisms and analysis of Duffy blood system and glucose-6-phosphate dehydrogenase deficiency in Mauritania
Albin Fontaine, Oum Kelthoum Mamadou Djigo, Nicolas Gomez, Ali Ould Mohamed Salem Boukhary, Leonardo Basco, Sébastien Briolant · 2025
Read Amplicon-based DNA sequencing to characterize Duffy antigen polymorphisms and analysis of Duffy blood system and glucose-6-phosphate dehydrogenase deficiency in Mauritania by Albin Fontaine, Oum Kelthoum Mamadou Djigo, Nicolas Gomez, Ali Ould Mohamed Salem Boukhary, Leonardo Basco, Sébastien Briolant (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12768377.txt.
Description
Albin Fontaine and colleagues use DNA sequencing to characterise blood group variants and an enzyme deficiency relevant to malaria elimination in Mauritania. Their 2025 study analyses nearly a thousand blood samples from two ethnic groups.
Both the Duffy blood antigen and the enzyme deficiency track with ethnic origin and affect vulnerability to one malaria parasite species. Sequencing predicted Duffy-negative status predominating in people of black African ancestry, while a minority of white Moors were negative. Combined patterns of the two traits were tabulated for each group, including women carrying one copy of the deficiency variant. The updated prevalence data guide national programs aiming to eliminate that malaria type.
Catalog record
| CREATOR | Albin Fontaine, Oum Kelthoum Mamadou Djigo, Nicolas Gomez, Ali Ould Mohamed Salem Boukhary, Leonardo Basco, Sébastien Briolant |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |