Internal Tissue Expansion Induces Outward Migration of ADSCs From the Subcutaneous Fat Flap to Promote Skin Regeneration of the Expanded Area
Haojing Tang, Zhixin Xue, Ye Li, Ziqing Dong, Yunjun Liao · 2025
Read Internal Tissue Expansion Induces Outward Migration of ADSCs From the Subcutaneous Fat Flap to Promote Skin Regeneration of the Expanded Area by Haojing Tang, Zhixin Xue, Ye Li, Ziqing Dong, Yunjun Liao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12767481.txt.
Description
Haojing Tang and co-authors study fat stem cells in skin expansion in rats in a 2025 paper. Surgeons stretch skin to repair large tissue losses. Expansion can fail when skin is thin, as after breast removal. Grafting fat first seems to help skin grow, for reasons not yet clear.
Four groups of rats tested fat transfer, expansion, both, or neither. Twenty rats per group gave skin and fat samples over four weeks. Tagged stem cells from fat were tracked as they moved. Fat-first groups showed better skin growth in the tests. Tagged cells migrated outward from fat into the skin layer. There they likely aided growth directly or through signal molecules. Cell signals can spur division and collagen building in skin. The authors offer this migration as a likely mechanism. Human trials would be the next proof step.
Catalog record
| CREATOR | Haojing Tang, Zhixin Xue, Ye Li, Ziqing Dong, Yunjun Liao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |