Pinocembrin as a novel anti-cancer agent: Exploring preclinical evidence along with therapeutic potential
Neelam Singla, Piyush Mittal, M Arockia Babu, Soumya V Menon, Subhashree Ray, Haider Ali, Manish Purohit, Kavita Goyal, Rakhi Mishra, Md Sadique Hussain, Arcot Rekha, Gaurav Gupta · 2025
Read Pinocembrin as a novel anti-cancer agent: Exploring preclinical evidence along with therapeutic potential by Neelam Singla, Piyush Mittal, M Arockia Babu, Soumya V Menon, Subhashree Ray, Haider Ali, Manish Purohit, Kavita Goyal, Rakhi Mishra, Md Sadique Hussain, Arcot Rekha, Gaurav Gupta (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12767260.txt.
Description
Singla and a team of colleagues reviewed pinocembrin, a plant flavonoid, as a possible cancer drug in twenty twenty-five. The compound occurs in propolis and pine species. In cell studies it triggers mitochondrial cell suicide, halts the cell cycle, and suppresses spread signals across several cancer lines, while animal tumors shrank without obvious toxicity.
The catch is delivery: swallowed pinocembrin is absorbed fast but heavily processed by the liver, leaving under ten percent available and a short half-life. Nano-carrier formulations changed that picture in rodents, raising availability up to fivefold and extending half-life substantially. Rat safety studies found no genetic damage and a high no-harm dose, and early human trials showed tolerability. The authors flag gaps in target validation, long-term safety, and prodrug design before clinical use.
Catalog record
| CREATOR | Neelam Singla, Piyush Mittal, M Arockia Babu, Soumya V Menon, Subhashree Ray, Haider Ali, Manish Purohit, Kavita Goyal, Rakhi Mishra, Md Sadique Hussain, Arcot Rekha, Gaurav Gupta |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |