Proneurogenic and microglial modulatory properties of botulinum neurotoxin in the hippocampus of aging experimental mice
Jerly Helan Mary Joseph, Mercy Priyadharshini Babu Deva Irakkam, Mahesh Kandasamy · 2025
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Description
Jerly Helan Mary Joseph, Mercy Priyadharshini Babu Deva Irakkam, and Mahesh Kandasamy study botulinum neurotoxin in aging mice in a 2025 paper. The toxin is best known for treating movement and muscle disorders. Recent work hints it may also help memory and ease anxiety in aging animals.
Treated mice were examined after four weeks for new neurons and microglia in the hippocampus. The treated group had more immature and newly matured neurons in the dentate gyrus. It also had fewer activated microglia and lower levels of two inflammatory markers. The authors link these shifts to the toxin's reported gains in thinking and mood.
Catalog record
| CREATOR | Jerly Helan Mary Joseph, Mercy Priyadharshini Babu Deva Irakkam, Mahesh Kandasamy |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |