Identification and Verification of Biomarkers Related to Polyamine Metabolism in Diabetic Nephropathy
Sen Zhou, Haiqian An, Hui Wei, Rong Wu, Zhe Wang, Minglong Liu, Tianxi Liu, Kan Li · 2025
Read Identification and Verification of Biomarkers Related to Polyamine Metabolism in Diabetic Nephropathy by Sen Zhou, Haiqian An, Hui Wei, Rong Wu, Zhe Wang, Minglong Liu, Tianxi Liu, Kan Li (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12767236.txt.
Description
Sen Zhou and seven co-authors search for gene markers of diabetic kidney disease in a 2025 study. The markers sought sit in pathways that break down polyamines, a family of cell chemicals whose leftovers can harm kidneys. Whether those genes mark the disease was unknown.
The team mined public gene datasets from patients and controls, crossing disease-linked changes with the polyamine gene set. Machine learning screens and accuracy curves narrowed the field to three genes. The three took part in several biological pathways and tied into immune cell patterns in the tissue. Drug guesses were also made from the markers. Lab tests on patient samples confirmed the genes' altered levels. The trio may seed future blood or urine tests for early kidney damage.
Catalog record
| CREATOR | Sen Zhou, Haiqian An, Hui Wei, Rong Wu, Zhe Wang, Minglong Liu, Tianxi Liu, Kan Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |