Investigation of an association between in vitro expression of TMEM154 and PARP14 genes and restriction of SRLV infection in primary skin cells of Carpathian goats
Magdalena Materniak-Kornas, Marlena Smagacz, Katarzyna Ropka-Molik, Aldona Kawęcka, Jacek Sikora, Jacek Michał Kuźmak · 2025
Read Investigation of an association between in vitro expression of TMEM154 and PARP14 genes and restriction of SRLV infection in primary skin cells of Carpathian goats by Magdalena Materniak-Kornas, Marlena Smagacz, Katarzyna Ropka-Molik, Aldona Kawęcka, Jacek Sikora, Jacek Michał Kuźmak (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12767165.txt.
Description
Magdalena Materniak-Kornas and five co-authors shared a study in twenty twenty-five. It asks why some goats resist a lentivirus that does real harm. Small ruminant lentiviruses hurt sheep and goat farming all over the world. For now, control means culling infected animals. Genes that give resistance could offer a kinder way. The team tested two genes as candidates for that role.
They grew skin cells from Carpathian goats. Some goats had high virus loads, some low, and some none. They infected the cell cultures with the flock's own virus subtype. They tracked how fast the virus copied itself. They tracked the activity of two genes, TMEM154 and PARP14, at the same time. If gene activity tracks with slow spread, the gene may in fact restrict infection. The work hunts for breeding markers for herds that resist by nature.
Catalog record
| CREATOR | Magdalena Materniak-Kornas, Marlena Smagacz, Katarzyna Ropka-Molik, Aldona Kawęcka, Jacek Sikora, Jacek Michał Kuźmak |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |